WEBINAR DESCRIPTION
Webinar Description
Two main ways lead to drug discovery:
the persistent lab work, which includes inspirational incidents,
and/or
the out of the box thinking. This inventive add has to be imported by pharma labs, being a must in drugs discovery today, when interdisciplinarity is an asset.
The webinar is the expression of scientific work with unbind interest and interdisciplinary research.
The neurotoxicity is a problem to handle in a better way. Firstly, because brain health is mandatory in postmodern tech civilization. The increase of mental health issues in all ages with respect to decades ago, is a complex question, pushing to wider inference of view points in neuroscience.
Also, because the huge amount of open knowledge stored in digital libraries is challenging the scientific work, uprising unexpected shortcuts.
Following an old but incompletely explored concept of intact and sliced brain, introduced by Mircea Steriade in late ninties, the webinar gives innovative insides about synergistic ways to handle neurotoxicity. Caring about the logical understanding of delivered plus value, the topic is structured in 5 chapters:
I.Observational Investigation: Data type may vary but explanation has to be always logical!
A. Classification criteria and examples of neurotoxicity
B. Neurotoxicity as side effect
II. Explanatory Models: patients are all different
III. Functional Observations: mathematics everywhere. Let's talk about Alzheimer, Parkinson, Autism
IV. Categories of new drugs which may help reduce neurotoxicity: the day's word is 'systemic'!
V. Pharma Lab - fostering personalized medicine in AI era:roadmaps to successfully handle neurotoxicity by procedural drugs discovery.
KEYNOTER
Dr. Adriana Climescu-Haulica is a mathematician known for her non standard approach in life sciences. Her doctoral work was acknowledged as the best thesis of the year from Mathematics Departement at Federal Polytehnic School of Lausanne (EPFL) in 1999. The subject, 'Stochastic Calculus for Random Signals Detection' is still actual, and opens to interdisciplinary research. She started her carrier as scientist for Communication Research Centre in Ottawa, applying her fundamental work to Signal Processing,Information Theory and Wireless Communication.
Her interest in Neuroscience started in 2004, while preparing a Neural Networks course for Polytechnic Institute in Grenoble. Curios to understand the physiological neuron, she get interested on spike time plasticity. Questionning the real interpretability of the electrical measurements, she get persuaded the field has to wait for more technically precise tools. Meanwhile, impressed by the brain functioning dependence on molecular mechanism, she embraced the exciting field of molecular biology. Her choice was to integrate as scientist the best Bioinformatics CNRS lab, Information Genomique et Structurale in Marseille, directed by Prof. Jean-Michel Claverie. Here she participated to a Sanofi project on identifying leads for drugs discovery in oncology. From now on, her main interest was personalized medicine. In 2011 she initiates a comprehensive project on neuro-endocrinology, sought as fundamental milestone for systemic molecular medicine. For 10 years she was the President and Director R&D of Bioclinome, an innovative french startup whose ambition, ahead of time, was to introduce large scale personalized medicine. She was awarded two innovation prizes and contributed for more than 30 peer reviewed publications, half of them as single author.
In 2021 Adriana founded Avantiv Limited in Cambridge UK, which proliferate mathematically rigorous methods in science to conteract ML/ AI industrial methods.
Due to the progress on monitoring with accuracy local brain activity, the time has come to present original findings on Neuroscience to interested scientists and healthcare entities, letting them make benefit of it. Specific work will be pursued by Avantiv team in collaborative forms, the webinar is a first step to establish joint work.